Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension.
Natalia J BraamsAzar KianzadJessie van WezenbeekJeroen N WesselsSamara M A JansenStine AndersenAnco BoonstraEsther J NossentJ Tim MarcusAhmed A BayoumyClarissa BecherMarie-José T H GoumansAsger AndersenAnton Vonk NoordegraafFrances S de ManHarm Jan BogaardLilian J MeijboomPublished in: Circulation. Heart failure (2023)
Although cellular hypertrophy regresses and diastolic stiffness normalizes after PEA, a relative increase in extracellular volume remains. Incomplete regression of diffuse RV interstitial fibrosis after PEA is accompanied by elevated levels of circulating collagen biomarkers, suggestive of active collagen turnover.
Keyphrases
- pulmonary hypertension
- pulmonary artery
- mycobacterium tuberculosis
- pulmonary arterial hypertension
- wound healing
- left ventricular
- blood pressure
- tissue engineering
- low grade
- atrial fibrillation
- coronary artery bypass grafting
- heart failure
- ejection fraction
- acute coronary syndrome
- coronary artery
- high grade
- postmenopausal women