Alterations in the Transcriptional Programs of Myeloma Cells and the Microenvironment during Extramedullary Progression Affect Proliferation and Immune Evasion.
Daeun RyuSeok Jin KimYourae HongAreum JoNayoung KimHee-Jin KimHae-Ock LeeKihyun KimWoong-Yang ParkPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
These data suggest that myeloma cells are equipped with specialized immune evasion mechanisms in cytotoxic microenvironments. Taken together, single-cell transcriptome analysis revealed transcriptional programs associated with aggressive myeloma progression that support autonomous cell proliferation and immune evasion.
Keyphrases
- induced apoptosis
- single cell
- cell proliferation
- cell cycle arrest
- multiple myeloma
- public health
- newly diagnosed
- transcription factor
- palliative care
- endoplasmic reticulum stress
- cell cycle
- oxidative stress
- electronic health record
- cell death
- high throughput
- big data
- deep learning
- heat shock protein
- anti inflammatory