The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications.

Ranin SaadHagar TadmorOffir ErtrachtNakhoul NakhoulNakhoul FaridFarber EvgenyShaul Atar

Published in: Journal of diabetes research (2022)

Hyperglycemia reduces LC3-II and ATG5 protein levels which contribute to deficiencies in the autophagy process, with development and progression of DN. SGLT2i significantly reduces progression of DN and onset of end-stage renal disease in T2DM patients, probably through its effect on autophagy.

Keyphrases

end stage renal disease
chronic kidney disease
peritoneal dialysis
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
type diabetes
amino acid
glycemic control
prognostic factors
mass spectrometry
patient reported outcomes
diabetic rats
protein protein
solid phase extraction