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Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions.

Eider DuñabeitiaAitor LandaRosa LópezClaudio Palomo
Published in: Organic letters (2022)
The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon-carbon bond forming reactions. The good performance of ureidoaminal-derived Brønsted bases in the Michael addition to nitroolefins affords these heterocyclic scaffolds with high skeleton diversity.
Keyphrases
  • capillary electrophoresis
  • ionic liquid
  • tissue engineering