Prior Exposure to Experimental Preeclampsia Increases Atherosclerotic Plaque Inflammation in Atherogenic Mice-Brief Report.
Lauren A BiwerJoshua J ManNicholas D CamardaBrigett V CarvajalS Ananth KarumanchiIris Z JaffePublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
In atherogenic LDLR-KO mice, exposure to sFlt1-induced preeclampsia during pregnancy increases future atherosclerotic plaque inflammation, supporting the concept that preeclampsia directly exacerbates atherosclerotic inflammation independent of preexisting risk factors. This mechanism may contribute to ischemic vascular disease in women after preeclampsia pregnancy.
Keyphrases
- pregnancy outcomes
- early onset
- oxidative stress
- risk factors
- pregnant women
- high fat diet induced
- coronary artery disease
- diabetic rats
- ischemia reperfusion injury
- polycystic ovary syndrome
- type diabetes
- high glucose
- adipose tissue
- low density lipoprotein
- insulin resistance
- metabolic syndrome
- drug induced
- blood brain barrier
- cerebral ischemia