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DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy.
Chang Yang
Wei Dong
Yan Wang
Xiaofei Dong
Xiaoxiao Xu
Xijie Yu
Jiawei Wang
Published in:
Osteoarthritis and cartilage (2024)
Our findings identified the crucial role of DDIT3-inhibited autophagy in condylar cartilage degradation during the development of TMJOA.
Keyphrases
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oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
extracellular matrix
pi k akt
cone beam computed tomography