A Three-Step Process to Facilitate the Enantioselective Assembly of Cis -Fused Octahydrophenanthrenes with a Quaternary Stereocenter.

A three-step process for the enantioselective assembly of cis -fused octahydrophenanthrenes with a quaternary stereocenter is reported. This synthetic strategy relies on a regioselective γ-alkylation, a one-pot sequence of asymmetric hydrogenation and oxidation, and an intramolecular enolate arylation to facilitate the rapid and enantioselective construction of cis -fused octahydrophenanthrene scaffolds with an arylated all-carbon quaternary stereocenter concisely and efficiently.