Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma.
Salvador AlejoBridgitte E PalaciosPrabhakar Pitta VenkataYi HeWenjing LiJessica D JohnsonChen YihongSridharan JayamohanUday P PratapKyra ClarkeYi ZouYingli LvKorri WeldonSuryavathi ViswanadhapalliZhao LaiZhenqing YeYidong ChenAndrea R GilbertTakayoshi SuzukiRajeshwar R TekmalWeixing ZhaoSiyuan ZhengRatna K VadlamudiAndrew J BrennerGangadhara R SareddyPublished in: Neuro-oncology (2023)
Our results provide evidence that KDM1A inhibition sensitizes GBM to TMZ via attenuation of DNA DSB repair pathways.