Nanomaterials have been proposed as key components in biosensing, imaging, and drug-delivery since they offer distinctive advantages over conventional approaches. The unique chemical and physical properties of graphene make it possible to functionalize and develop protein transducers, therapeutic delivery vehicles, and microbial diagnostics. In this study we evaluate reduced graphene oxide (rGO) as a potential nanomaterial for quantification of microRNAs including their structural differentiation in vitro in solution and inside intact cells. Our results provide evidence for the potential use of graphene nanomaterials as a platform for developing devices that can be used for microRNA quantitation as biomarkers for clinical applications.
Keyphrases
- reduced graphene oxide
- gold nanoparticles
- induced apoptosis
- drug delivery
- cell cycle arrest
- endoplasmic reticulum stress
- physical activity
- microbial community
- ms ms
- high resolution
- cell death
- room temperature
- cancer therapy
- carbon nanotubes
- small molecule
- energy transfer
- reactive oxygen species
- cell proliferation
- protein protein
- simultaneous determination
- binding protein
- drug release