Bosutinib, an SRC inhibitor, induces caspase-independent cell death associated with permeabilization of lysosomal membranes in melanoma cells.

Shunsuke NoguchiS ShibutaniK FukushimaT MoriM IgaseT Mizuno

Published in: Veterinary and comparative oncology (2017)

Our data suggest that Bosu induces the cell death through induction of LMP in melanoma cells and is a promising therapeutic agent for treatment of melanoma in both dogs and humans.

Keyphrases

cell death
cell cycle arrest
epstein barr virus
electronic health record
tyrosine kinase
big data
machine learning
induced apoptosis