A total neoadjuvant chemotherapy approach is associated with improved recurrence-free survival in patients with colorectal peritoneal metastases undergoing cytoreductive surgery and HIPEC.
David N HannaRebekah C MacfieMuhammad O GhaniAndrew HerminaAlexander MinaDa Eun ChaChristina E BaileyNoah CohenDaniel LabowBenjamin GolasUmut SarpelDeepa MaggeKamran IdreesPublished in: Journal of surgical oncology (2022)
In this retrospective study, a TNT approach was associated with improved RFS, but not OS when compared with a SAND approach. Further prospective studies are needed to examine these systemic chemotherapeutic approaches in patients with CPM undergoing CRS-HIPEC.