Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres.
Iulia PopescuHannah MannemSpencer A WintersAki HojiFernanda SilveiraEmily McNallyMatthew R PipelingElizabeth A LendermonMatthew R MorrellJoseph M PilewskiVidya Sagar HanumanthuYingze ZhangSwati GulatiPali D ShahCarlo J IasellaChristopher R EnsorMary ArmaniosJohn F McDyerPublished in: American journal of respiratory and critical care medicine (2019)
Because the short telomere defect has been linked to the pathogenesis of IPF in some cases, our data indicate that impaired CMV immunity may be a systemic manifestation of telomere-mediated disease in these patients. Identifying this high-risk subset of LTRs has implications for risk assessment, management, and potential strategies for averting post-transplant CMV morbidities.
Keyphrases
- idiopathic pulmonary fibrosis
- risk assessment
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- interstitial lung disease
- prognostic factors
- electronic health record
- peritoneal dialysis
- heavy metals
- machine learning
- big data
- patient reported outcomes
- artificial intelligence
- deep learning