Potential therapeutic efficacy of pachymic acid in chronic kidney disease induced in rats: role of Wnt/β-catenin/renin-angiotensin axis.

Nahla N YounisHoda E Mohamed Mohamed A ShaheenAsmaa M AbdelghafourSally K Hammad

Published in: The Journal of pharmacy and pharmacology (2021)

These results suggest a new therapeutic benefit of PA in ameliorating CKD in rats through its up-regulatory effect on renal klotho thereby preventing Wnt/β-catenin reactivation and RAS gene expression. PA/LOS combination provided an additional inhibition of Wnt/β-catenin signalling and its downstream targets.

Keyphrases

cell proliferation
gene expression
epithelial mesenchymal transition
stem cells
angiotensin converting enzyme
chronic kidney disease
dna methylation
high glucose
transcription factor
drug induced
oxidative stress