Particular Aspects Related to CD4+ Level in a Group of HIV-Infected Patients and Associated Acute Coronary Syndrome.
Mircea BajdechiAdriana GurgheanVlad BatailaAlexandru ScafaGeorgiana-Elena BajdechiRoxana RadoiAnca Cristiana OpreaValentin ChioncelIuliana MateescuLucia ZekraRoxana CernatIrina Magdalena DumitruSorin RuginaPublished in: Diagnostics (Basel, Switzerland) (2023)
People living with HIV infection are at high risk for cardiovascular events due to inflammation and atherosclerosis. Also, some antiretroviral therapies may contribute to the risk of cardiovascular complications. Immune status is highly dependent on the level of lymphocyte T helper CD4+. There are data suggesting that immune status and CD4+ cell count may be involved in the development of cardiovascular complications in these patients. Our study is longitudinal and retrospective and included a total number of 50 patients with HIV infection associated with acute coronary syndrome, divided into two subgroups based on the nadir of CD4+ cells. This study analyzes the relationship between the immune status of HIV patients, assessed by the nadir of the CD4+ T-cell count, and the outcome of these patients. Also, secondary endpoints were the assessment of the magnitude of coronary lesions and of thrombotic and bleeding risk assessed by specific scores. Clinical and biological parameters and also the extension and complexity of coronary lesions were assessed. Although patients with poor immune status had more complex coronary lesions and increased operative risk and bleeding risk at one year, this was not associated with significant differences in major adverse cardiac and cerebrovascular events at the 30-day and 1-year outcomes.
Keyphrases
- end stage renal disease
- acute coronary syndrome
- coronary artery disease
- cardiovascular events
- ejection fraction
- hiv infected patients
- antiretroviral therapy
- chronic kidney disease
- newly diagnosed
- coronary artery
- cardiovascular disease
- peritoneal dialysis
- prognostic factors
- type diabetes
- emergency department
- hiv positive
- human immunodeficiency virus
- machine learning
- aortic stenosis
- hepatitis c virus
- patient reported outcomes
- risk factors
- single cell
- cell death
- hiv aids
- signaling pathway
- south africa
- antiplatelet therapy
- electronic health record
- artificial intelligence
- hiv testing
- big data