Ultrastructural Axon-Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation.
Aletta M R van den BoschSophie HümmertAnna Maria SteyerTorben RuhwedelJörg HamannJoost J F M SmoldersKlaus-Armin NaveChristine StadelmannMaarten H P KoleWiebke MöbiusInge HuitingaPublished in: Annals of neurology (2022)
These data suggest that in MS NAWM myelin detachment and uncompact myelin wrapping occurs, potassium channels are unmasked at the nodes of Ranvier, and axonal energy demand is increased, or mitochondrial transport is stagnated, accompanied by increased presence of activated and phagocytic microglia and T cells. These subclinical alterations to the axon-myelin unit in MS NAWM may contribute to disease progression. ANN NEUROL 2023.