Mitochondrial choline import regulates purine nucleotide pools via SLC25A48.
Anthony R P VerkerkeXu ShiIchitaro AbeRobert E GersztenShingo KajimuraPublished in: bioRxiv : the preprint server for biology (2024)
SLC25A48 is required for mitochondrial choline uptake.Mitochondrial choline uptake regulates one-carbon contribution to purine nucleotide synthesis.Brown fat thermogenesis requires mitochondrial choline catabolism for respiratory capacity.Cancer cells require mitochondrial choline uptake for cell survival.
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