Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation.

Akihiro HoshinoBenoît Heid PicardSophia PolychronopoulouCharikleia KelaidiSaba AzarnoushSven KrackerFrédéric Rieux-LaucatDavid BoutboulSylvain Latour

Published in: The Journal of allergy and clinical immunology (2024)

Disturbed IKZF1 phosphorylation represents a novel GOF mechanism (GOF by loss of phosphorylation (termed as GOF-LOP) associated with immune dysregulation, highlighting the regulatory role of IKZF1 during cell cycle progression through phosphorylation.

Keyphrases

cell cycle
acute lymphoblastic leukemia
protein kinase
cell proliferation