Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers.
Frank JessenSteffen WolfsgruberLuca KleineindamAnnika SpottkeSlawek AltensteinClaudia BartelsMoritz BergerFrederic BrosseronMarcel DaamenMartin DichgansLaura DobischMichael EwersFriederike FenskiKlaus FliessbachSilka D FreieslebenWenzel GlanzDoreen GörßSelim GürselDaniel JanowitzIngo KilimannXenia KobelevaAndrea LohseFranziska MaierCoraline MetzgerMatthias MunkLukas PreisCarolin SanzenbacherEike SpruthBoris RauchmannRuth VukovichRenat YakupovAnne-Sophie WeyrauchGabriel ZieglerMatthias SchmidChristoph LaskeRobert PerneczkyAnja SchneiderJens WiltfangStefan TeipelKatharina BürgerJosef PrillerOliver PetersAlfredo RamirezHenning BoeckerMichael T HenekaMichael WagnerEmrah DüzelPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
Our data suggests that SCD serves the identification of stage 2 of the AD continuum and that stage 2, operationalized as SCD-A+, is associated with subtle, but extended impact of AD pathology in terms of neurodegeneration, symptoms and clinical progression.