RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.

Abhishek Singh SengarManish KumarChetna RaiSreemoyee ChakrabortiDinesh KumarPranesh KumarSukhes MukherjeeKausik MondalAdele StewartBiswanath Maity

Published in: Journal of translational medicine (2024)

Together, these data implicate RGS6 as a driver of nucleolar stress-dependent cell death in cardiomyocytes via its ability to modulate Nucleolin. This work represents the first demonstration of a functional role for an RGS protein in the nucleolus and identifies the RGS6/Nucleolin interaction as a possible new therapeutic target in the prevention of cardiotoxicity.

Keyphrases

cell death
stress induced
electronic health record
gene expression
high glucose
dna methylation
binding protein