Drug-Drug Interaction Studies of Esmethadone (REL-1017) Involving CYP3A4- and CYP2D6-Mediated Metabolism.

Nicola FerriSara De MartinJames StuartSergio TraversaFranco FolliMarco PappagalloCedric O'GormanClotilde GuidettiAndrea MattareiCharles E InturrisiPaolo L Manfredi

Published in: Drugs in R&D (2023)

In summary, esmethadone demonstrated a negligible effect on CYP3A4 induction and its metabolism was not meaningfully affected by strong CYP3A4 inhibitors while it increased exposure of CYP2D6-metabolized drugs.

Keyphrases

drug induced
adverse drug
emergency department
case control