Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion.

Annachiara SarnellaYlenia FerraraLuigi AulettaSandra AlbaneseLaura CerchiaVincenzo AlterioGiuseppina De SimoneClaudiu T SupuranAntonella Zannetti

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our results highlight the ability of SLC-0111 to sensitize HNSCC to cisplatin by hindering hypoxia-induced signaling network that are shared among mechanisms involved in therapy resistance and metastasis.

Keyphrases

high grade
cell migration
stem cells
cell therapy
replacement therapy