Scission-Enhanced Molecular Imaging (SEMI).
Jeremy M QuintanaJonathan C T CarlsonElla ScottThomas S C NgMiles A MillerRalph WeisslederPublished in: Bioconjugate chemistry (2024)
Positron emission tomography (PET) imaging methods have advanced our understanding of human biology, while targeted radiotherapeutic drug treatments are now routinely used clinically. The field is expected to grow considerably based on an expanding repertoire of available affinity ligands, radionuclides, conjugation chemistries, and their FDA approvals. With this increasing use, strategies for dose reduction have become of high interest to protect patients from unnecessary and off-target toxicity. Here, we describe a simple and powerful method, scission-enhanced molecular imaging (SEMI). The technique allows for rapid corporeal elimination of radionuclides once imaging or theranostic treatment is completed and relies on "click-to-release" bioorthogonal linkers.
Keyphrases
- pet imaging
- positron emission tomography
- computed tomography
- end stage renal disease
- ejection fraction
- endothelial cells
- newly diagnosed
- photodynamic therapy
- emergency department
- fluorescence imaging
- cancer therapy
- patient reported outcomes
- mass spectrometry
- combination therapy
- induced pluripotent stem cells
- replacement therapy
- electronic health record