Sex-specific associations of asthma acquisition with changes in DNA methylation during adolescence.

Rutu RathodFarnaz SolatikiaHongmei ZhangAlemayehu WoldeLatha KadalayilWilfried KarmausSusan EwartRyan ArathimosCaroline ReltonSusan RingAlexander John HendersonSyed Hasan ArshadJohn W Holloway

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

Gender reversal in asthma acquisition is associated with opposite changes in DNAm (males vs females) from pre- to post-adolescence at asthma-associated CpGs. These CpGs are potential biomarkers of sex-specific asthma acquisition in adolescence.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
dna methylation
depressive symptoms
gene expression
cystic fibrosis
mental health
nk cells