Prevalence of Coronary Endothelial and Microvascular Dysfunction in Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease Is Confirmed by a New Cohort: The NHLBI-Sponsored Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD).
R David AndersonJohn W PetersenPuja K MehtaJanet WeiB Delia JohnsonEileen M HandbergSaibal KarBruce SamuelsBabak AzarbalKamlesh KothawadeSheryl F KelseyBarry SharafLeslee J ShawGeorge SopkoC Noel Bairey MerzCarl J PepinePublished in: Journal of interventional cardiology (2019)
This study confirms prevalence of CMD in the contemporary WISE-CVD cohort similar to that of the original WISE cohort, despite a lower risk factor burden in WISE-CVD. Because these coronary functional abnormalities predict major adverse cardiac events, clinical trials of therapies targeting these abnormalities are indicated.
Keyphrases
- coronary artery disease
- risk factors
- coronary artery
- clinical trial
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- oxidative stress
- aortic stenosis
- endothelial cells
- emergency department
- type diabetes
- case report
- polycystic ovary syndrome
- pregnant women
- pregnancy outcomes
- physical activity
- depressive symptoms