Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality.
Udayanga Sanath Kankanam GamageShu HashimotoYuki MiyamotoTatsuya NakanoMasaya YamanakaHideki KitajiYuki TakadaHiroshi MatsumotoAkiko KoikeManabu SatohMasako IchishiMasatoshi WatanabeYoshiharu MorimotoPublished in: Journal of assisted reproduction and genetics (2024)
Injection of ASC-mitochondria into oocytes may be a promising technique to support developmental potential without causing adverse epigenetic events in the offspring in mice. However, before considering clinical application, additional safety screening using larger animals or non-human primates is essential.
Keyphrases
- stem cells
- endothelial cells
- cell death
- reactive oxygen species
- endoplasmic reticulum
- dna methylation
- cell therapy
- gene expression
- high fat diet
- insulin resistance
- high fat diet induced
- induced pluripotent stem cells
- bone marrow
- adipose tissue
- ultrasound guided
- emergency department
- quality improvement
- nlrp inflammasome
- type diabetes
- mesenchymal stem cells
- risk assessment