The citrus flavanone naringenin prevents the development of morphine analgesic tolerance and conditioned place preference in male rats.
Atena AlifarsangiSaeed Esmaeili-MahaniVahid SheibaniRazieh KooshkiPublished in: The American journal of drug and alcohol abuse (2020)
Our results suggest that naringenin may have a potential anti-tolerant/anti-addiction property against chronic morphine misuse and that this preventive effect is associated with its anti-neuroinflammatory effects.