Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition.

Ming-Chia ChuWei-Chang MaoHan-Fang WuYun-Chi ChangTing-I LuChi-Wei LeeYueh-Jung ChungTsung-Han HsiehHsun-Shuo ChangYih-Fung ChenChia-Hsien LinChih-Wei TangHui Ching Lin

Published in: Pharmacological reports : PR (2023)

Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.

Keyphrases

histone deacetylase
high glucose
diabetic rats
oxidative stress
drug induced
cerebral ischemia
endothelial cells
type diabetes
blood pressure
resting state
subarachnoid hemorrhage
functional connectivity
skeletal muscle
insulin resistance
blood brain barrier