TGR5 Protects Against Colitis in Mice, but Vertical Sleeve Gastrectomy Increases Colitis Severity.

Darline GaribayKarolina E ZaborskaMichael ShanahanQiaonan ZhengKatie M KellyDavid C MontroseAndrew J DannenbergAndrew D MillerPraveen SethupathyBethany P Cummings

Published in: Obesity surgery (2020)

While our data demonstrate that TGR5 protects against colitis, they also demonstrate that VSG potentiates chemically induced colitis in mice. These data suggest that individuals undergoing VSG may be at increased risk for developing colitis; however, further study is needed.

Keyphrases

ulcerative colitis
electronic health record
high fat diet induced
big data
data analysis
artificial intelligence