Dysregulation of metalloproteinases in spinal ligament degeneration.
Chao WangZiran WeiTengbo YuLu ZhangPublished in: Connective tissue research (2023)
The dysregulation of metalloproteinases and their endogenous inhibitors may affect ligament degeneration by involving several interrelated processes, represented by ECM degradation, fibroblast proliferation, and osteogenic differentiation. Antagonists of the key targets of the processes may in turn ease ligament degeneration.