Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer.
Jad I BelleDevashish SenJohn M BaerXiuting LiuVarintra E LanderJiayu YeBlake E SellsBrett L KnolhoffAhmad FaizLiang-I KangGuhan QianRyan C FieldsLi DingHyun KimPaolo P ProvenzanoSheila A StewartDavid G DeNardoPublished in: Cancer discovery (2024)
CAF heterogeneity in PDAC remains poorly understood. In this study, we identify a novel subpopulation of senescent CAFs that promotes PDAC progression and immunosuppression. Targeting CAF senescence in combination therapies could increase tumor vulnerability to chemo- or immunotherapy. See related article by Ye et al.