Bhlhe40: Gatekeeper of the GC.

Published in: The Journal of experimental medicine (2021)

The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211406) report that Bhlhe40 restrains GC output through distinct regulatory roles in both arms of the response.

Keyphrases

gas chromatography
induced apoptosis
cell cycle arrest
transcription factor
dendritic cells
cell death
endoplasmic reticulum stress
high resolution
tandem mass spectrometry
solid phase extraction