Impact of lymphopenia on survival for elderly patients with glioblastoma: A secondary analysis of the CCTG CE.6 (EORTC 26062-22061, TROG03.01) randomized clinical trial.
Andrew J SongKeyue DingIyad AlnahhasNormand J LaperriereJames PerryWarren P MasonChad WinchChris J O'CallaghanJohan J MentenAlba A BrandesClaire PhillipsMichael F FayRyo NishikawaDavid OsobaJ Gregory CairncrossWilson RoaWolfgang WickWenyin ShiPublished in: Neuro-oncology advances (2021)
Development of post-RT lymphopenia is associated with addition of TMZ and baseline lymphopenia and not with RT alone in patients treated with short-course radiation. However, regardless of MGMT status, only baseline lymphopenia is associated with worse OS, which may be considered as a prognostic biomarker for elderly glioblastoma patients.