Age-related rhesus macaque models of COVID-19.

Pin YuFeifei QiYanfeng XuFengdi LiPeipei LiuJiayi LiuLinlin BaoWei DengHong GaoZhiguang XiangChong XiaoQi LvShuran GongJiangning LiuZhiqi SongYajin QuJing XueQiang WeiMingya LiuGuanpeng WangShunyi WangHaisheng YuXing LiuBaoying HuangWenling WangLi ZhaoHuijuan WangFei YeWeimin ZhouWei ZhenJun HanGuizhen WuQi JinJianwei WangWenjie TanChuan Qin

Published in: Animal models and experimental medicine (2020)

SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
small molecule
early onset
intensive care unit