Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β.
Kanako ShinnoYuri MiuraKoichi M IijimaEmiko SuzukiKanae AndoPublished in: bioRxiv : the preprint server for biology (2024)
Loss of axonal mitochondria impairs autophagy and accumulates proteins in the axonLoss of axonal mitochondria upregulates eIF2β and downregulates p-eIF2αNeuronal upregulation of eIF2β induces autophagic defects and locomotor dysfunctionLowering eIF2β rescues autophagic defects caused by loss of axonal mitochondria.