Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies.

Fatma Mohamed ElsenosyGhada Ahmed AbdelbaryAhmed Hassen Elshafeey Ibrahim ElsayedAhmed Roshdy Fares

Published in: International journal of nanomedicine (2020)

Accordingly, intranasal DLX in situ cubo-gel can be considered as an innovative nano-carrier delivery system for bioavailability enhancement and efficient brain targeting of DLX to maximize its effect.

Keyphrases

cancer therapy
resting state
white matter
wound healing
drug delivery
functional connectivity
cerebral ischemia
hyaluronic acid
pet imaging
case control
brain injury
blood brain barrier
positron emission tomography