Assessing the immune cell subset and genetic mutations in palindromic rheumatism negative for rheumatoid factor and anti-citrullinated antibodies.
Chin-An YangJu-Pi LiYi-Hua LaiYa-Ling HuangChien-Yu LinJoung-Liang LanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
In seronegative PR patients, we identified a distinct CD14+CD11b+CD36+ subset, which can induce inflammatory response under stress and exert anti-inflammatory effects after phagocytosis of apoptotic cells, and a CD4+CD25-CD69+ T cell subset with pro- and anti-inflammation properties. Individuals harboring genetic mutations involving epigenetic modification, potentiation and resolution of stress-induced inflammation/ apoptosis, and dysregulated ER stress response could be predisposed to seronegative PR.
Keyphrases
- stress induced
- oxidative stress
- cell cycle arrest
- inflammatory response
- cell death
- induced apoptosis
- end stage renal disease
- endoplasmic reticulum stress
- genome wide
- chronic kidney disease
- newly diagnosed
- anti inflammatory
- gene expression
- peritoneal dialysis
- prognostic factors
- copy number
- rheumatoid arthritis
- toll like receptor
- patient reported outcomes
- breast cancer cells