Autonomic impairment in primary lateral sclerosis.
Hebatallah R RashedNathan P StaffMargherita MiloneMichelle L MauermannSarah BeriniWilliam P CheshireElizabeth A CoonRobert D FealeyEric SorensonJeremy Cutsforth-GregoryEduardo E BenarrochPaola SandroniPhillip A LowWolfgang SingerKamal ShoumanPublished in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2024)
We found evidence of frequent autonomic dysfunction in primary lateral sclerosis, which is generally of modest severity akin to prior reports for amyotrophic lateral sclerosis, but more commonly in a pattern consistent with preganglionic/ganglionic localization. This suggests that primary lateral sclerosis, as with amyotrophic lateral sclerosis, is a multisystem disease that affects the autonomic nervous system.