Fixed dose rivaroxaban can be used in extremes of bodyweight: A population pharmacokinetic analysis.

Victoria SpeedBruce GreenLara N RobertsSarah WoolcombeJohn K Bartoli-AbdouSarah BarsamRosalind ByrneEmma GeeJulia CzuprynskaAlison BrownSinead DuffyBipin VadherRachna PatelValerie ScottAnna GazesRaj K PatelRoopen AryaJignesh P Patel

Published in: Journal of thrombosis and haemostasis : JTH (2021)

Our work demonstrates rivaroxaban can be used at extremes of bodyweight provided renal function is satisfactory. We recommend that the ISTH SSC revises the current guidance with respect to rivaroxaban at extremes of body size.

Keyphrases

venous thromboembolism
atrial fibrillation
pulmonary embolism
data analysis