Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles.

Qi YangYalan LuoPeng GeBowen LanJin LiuHaiyun WenYinan CaoZhenxuan SunGuixin ZhangHuiming YuanLihua ZhangHailong Chen

Published in: International journal of nanomedicine (2023)

The mechanism of action of EMO is observed to have a significant impact on the miRNA expression profile of Exos derived from plasma and BALF in SAP rats. NOVEL-rno-miR-29a-3p, which is specific to Exos, and is derived from BALF, may play a crucial role in the therapeutic efficacy of EMO.

Keyphrases

liver failure
drug induced
early onset
respiratory failure
mouse model