The role of functional thyroid capacity in pituitary thyroid feedback regulation.
Rudolf HoermannJohn E M MidgleyRolf LarischJohannes Wolfgang Christian DietrichPublished in: European journal of clinical investigation (2018)
Functional thyroid capacity and preferential T3 generation are essential elements in adjusting the sensitivity of hypothalamic-pituitary-thyroid feedback control and balancing system equilibria. This suggests that the indirect regulatory role of glandular T3 co-secretion exceeds its quantitative contribution to the thyroid hormone pool. Implications for clinical practice extend to the diagnostic use of TSH in patients with impaired thyroid reserve.