iPSC-Based Modeling of Variable Clinical Presentation in Hypertrophic Cardiomyopathy.

Rubén EscribáJosé María Larrañaga-MoreiraYvonne Richaud-PatinLéa Pourchet Ioannis LazisSenda Jiménez-DelgadoAlba Morillas-GarcíaMartín Ortiz-GengaJuan Pablo OchoaDavid Carreras Guillermo Javier Pérez José Luis de la Pompa Ramón Brugada Lorenzo Monserrat Roberto Barriales Villa Ángel Raya

Published in: Circulation research (2023)

. Overall, our studies show that iPSC-based modeling of clinically discordant subjects provides a unique platform to functionally assess the effect of genetic modifiers.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
induced pluripotent stem cells
genome wide
copy number
case control
dna methylation