Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD.
Layanne C C AraujoKarla B FeitosaGilson M MurataIsadora C FurigoSimone A TeixeiraCamila F LucenaLuciene M RibeiroMarcelo N MuscaráSoraia K P CostaJosé DonatoSilvana BordinRui CuriCarla Roberta de Oliveira CarvalhoPublished in: Scientific reports (2018)
We investigated the effect of the crude herbal extract from Uncaria tomentosa (UT) on non-alcoholic fatty liver disease (NAFLD) in two models of obesity: high fat diet (HFD) and genetically obese (ob/ob) mice. Both obese mouse models were insulin resistant and exhibited an abundance of lipid droplets in the hepatocytes and inflammatory cell infiltration in the liver, while only the HFD group had collagen deposition in the perivascular space of the liver. UT treatment significantly reduced liver steatosis and inflammation in both obese mouse models. Furthermore, serine phosphorylation of IRS-1 was reduced by 25% in the HFD mice treated with UT. Overall, UT treated animals exhibited higher insulin sensitivity as compared to vehicle administration. In conclusion, Uncaria tomentosa extract improved glucose homeostasis and reverted NAFLD to a benign hepatic steatosis condition and these effects were associated with the attenuation of liver inflammation in obese mice.
Keyphrases
- high fat diet
- adipose tissue
- insulin resistance
- oxidative stress
- high fat diet induced
- metabolic syndrome
- type diabetes
- weight loss
- mouse model
- obese patients
- skeletal muscle
- weight gain
- stem cells
- cell therapy
- high resolution
- mesenchymal stem cells
- wastewater treatment
- body mass index
- anti inflammatory
- physical activity
- blood glucose
- wound healing
- microbial community