Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy.

K Laxmi SwethaSwati SharmaRajdeep ChowdhuryAniruddha Roy

Published in: Pharmacological reports : PR (2020)

This study indicates that DTX + DSF combination therapy can effectively sensitize cancer cells by hyper inducing autophagy through ROS generation and can be developed as a therapeutic strategy for cancer treatment in the future.

Keyphrases

cell death
combination therapy
breast cancer cells
endoplasmic reticulum stress
dna damage
signaling pathway
oxidative stress
reactive oxygen species
current status