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The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.

Barbara CascellaSoon Goo LeeSukrit SinghJoseph M JezLiviu M Mirica
Published in: Chemical communications (Cambridge, England) (2018)
JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.
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