Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development.

Nicola A PhilbrookAna NikolovskaRebecca D MaciverChristine L BelangerLouise M Winn

Published in: Birth defects research (2019)

These results further characterize the effects of VPA on heart development and suggest that alterations in Mef2c gene expression, at least on GD 16, do not mediate VPA-induced cardiotoxicity in CD-1 mice.

Keyphrases

gene expression
heart failure
dna methylation
atrial fibrillation
high glucose
type diabetes
diabetic rats
oxidative stress
insulin resistance
high fat diet induced
endothelial cells