P-FAB: A Fiber-Optic Biosensor Device for Rapid Detection of COVID-19.

Divagar MuruganHimanshu BhatiaV V R SaiJitendra Satija

Published in: Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology (2020)

Rapid and low-cost diagnosis of COVID-19 is essential to identify the infected subjects, particularly the asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to RT-PCR, offer only limited help due to high false positives. We propose to exploit our field-deployable/portable plasmonic fiber-optic absorbance biosensor (P-FAB) platform for one-step, wash-free detection of SARS-CoV-2 virus particles directly in saliva sample with minimal sample pre-processing.

Keyphrases

sars cov
low cost
label free
loop mediated isothermal amplification
coronavirus disease
sensitive detection
respiratory syndrome coronavirus
gold nanoparticles
optical coherence tomography
quantum dots
real time pcr
optic nerve
simultaneous determination
energy transfer
mass spectrometry