Solid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cells.
Rayane GanassinVictor Carlos Mello da SilvaVictor Hugo Sousa AraújoGiulia Rosa TavaresPatrícia Bento Da SilvaPaolin Rocio Cáceres-VélezJoaquin E Martínez PorcelRosângela Correa RodriguesPatrizia AndreozziRichard Perosa FernandesBruno Fonseca-SantosSergio Enrique MoyaRicardo Bentes de AzevedoMarlus ChorilliLuís Alexandre MuehlmannPublished in: Nanomedicine (London, England) (2022)
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro . Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.
Keyphrases
- induced apoptosis
- sentinel lymph node
- computed tomography
- contrast enhanced
- image quality
- cell cycle arrest
- dual energy
- magnetic resonance imaging
- oxidative stress
- squamous cell carcinoma
- single molecule
- positron emission tomography
- endoplasmic reticulum stress
- drug delivery
- cell death
- deep learning
- signaling pathway
- early stage
- radiation therapy
- optical coherence tomography
- lymph node
- pi k akt
- mass spectrometry
- single cell
- wound healing