Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward.
Amila K NanayakkaraHelen W BoucherVance G FowlerAmanda JezekKevin OuttersonDavid E GreenbergPublished in: CA: a cancer journal for clinicians (2021)
Infection is the second leading cause of death in patients with cancer. Loss of efficacy in antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing success of cancer therapy. In this review, the authors focus on recent updates on the impact of antibiotic resistance in the cancer setting, particularly on the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.). This review highlights the health and financial impact of antibiotic resistance in patients with cancer. Furthermore, the authors recommend measures to control the emergence of antibiotic resistance, highlighting the risk factors associated with cancer care. A lack of data in the etiology of infections, specifically in oncology patients in United States, is identified as a concern, and the authors advocate for a centralized and specialized surveillance system for patients with cancer to predict and prevent the emergence of antibiotic resistance. Finding better ways to predict, prevent, and treat antibiotic-resistant infections will have a major positive impact on the care of those with cancer.
Keyphrases
- pseudomonas aeruginosa
- acinetobacter baumannii
- papillary thyroid
- multidrug resistant
- klebsiella pneumoniae
- staphylococcus aureus
- healthcare
- palliative care
- cancer therapy
- squamous cell
- end stage renal disease
- drug resistant
- biofilm formation
- escherichia coli
- gram negative
- childhood cancer
- peritoneal dialysis
- mental health
- lymph node metastasis
- health information
- patient reported outcomes
- risk assessment
- chronic pain
- antimicrobial resistance
- pain management
- candida albicans