A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders.

Ron NudelRosa Lundbye AllesøeWesley K ThompsonThomas WergeSimon RasmussenMichael Eriksen Benros

Published in: Journal of translational medicine (2021)

Our results suggest that classical HLA alleles do not play a large role in the etiology of severe infections. The discordant association trends with autoimmune disease for some alleles could contribute to mechanistic theories of disease etiology.

Keyphrases

multiple sclerosis
drug induced
early onset
gene expression