A novel furo[3,2- c ]pyridine-based AIE photosensitizer for specific imaging and photodynamic ablation of Gram-positive bacteria.
Ming-Yu WuYun WangLi-Juan WangJia-Li WangFeng-Wei XiaShun FengPublished in: Chemical communications (Cambridge, England) (2022)
An Rh-catalyzed tandem reaction was performed to construct an AIE-active furo[2,3- c ]pyridine-based photosensitizer, named LIQ-TF. LIQ-TF showed near-infrared emission with high quantum yield, and high 1 O 2 and ˙OH generation efficiency, and could be used for specific imaging and photodynamic ablation of Gram-positive bacteria in vitro and in vivo , showing great potential for combating multiple drug-resistant bacteria.
Keyphrases
- drug resistant
- multidrug resistant
- photodynamic therapy
- gram negative
- high resolution
- acinetobacter baumannii
- cancer therapy
- fluorescent probe
- living cells
- fluorescence imaging
- molecular dynamics
- pseudomonas aeruginosa
- room temperature
- drug delivery
- atrial fibrillation
- climate change
- human health
- energy transfer
- electron transfer